{"created":"2023-06-19T06:41:41.489142+00:00","id":11,"links":{},"metadata":{"_buckets":{"deposit":"51ec5c70-74a4-4f7c-8c1a-84455090b544"},"_deposit":{"created_by":5,"id":"11","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"11"},"status":"published"},"_oai":{"id":"oai:opcnr.repo.nii.ac.jp:00000011","sets":["1:6"]},"author_link":["22","23","15"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"27","bibliographicPageStart":"23","bibliographic_titles":[{"bibliographic_title":"沖縄県立看護大学紀要"},{"bibliographic_title":"Journal of Okinawa Prefectural College of Nursing","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To examine the importance of activation of cyclic GMP-dependent protein kinase (protein kinase G) by cyclic GMP in relaxation of vascular smooth muscle by nitroglycerin and nitroprusside, effects of Rp-8-Br-guanosine 3' ,5'-cyclic monophosphorothioate (Rp-8-Br-cGMPS), a selective, membrane permeable inhibitor of activation of protein kinase G by cyclic GMP, were studied using the isolated ring preparations of the rat aorta. Relaxation of high K^+ -contracted preparations by nitroglycerin and nitroprusside which has been repeatedly shown to occur in association with lowering of Ca^<2+> sensitivity of contractile protein was effectively counteracted by Rp-8-Br-cGMPS in harmony with our recent findings on the intimate connection of Ca^<2+> sensitivity lowering with activation of protein kinase G, while relaxation of phenylephrine-contracted preparations generally considered to proceed in connection with lowering of intracellular concentrations of Ca^<2+> was not.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"血管平滑筋のニトログリセリン､ニトロプルシッドによる弛緩におけるcyclic GMP依存性プロテインキナーゼ(プロテインキナーゼG)の重要性を確かめる為､ラット大動脈の摘出リング標本を用いcyclic GMPによるプロテインキナーゼGの活性化を選択的に抑制する､膜透過性の抑制薬であるRp-8-Br-guanosine 3',5'-cyclic monophosphorothioate(Rp-8-Br-cGMPS)の作用について検討した。収縮蛋白のCa^<2+>感受性低下と関連して起こる事が繰り返し示されている､高濃度K^+で収縮させた標本のニトログリセリン､ニトロプルシッドによる弛緩は､Rp-8-Br-cGMPSによって著明に抑制された｡これはCa^<2+>感受性の低下は､プロテインキナーゼGの活性化と密接に結びついているという我々の最近の所見(Kawada, Toyosato, Omedul Islam, Yoshida and Imai, 1997)と一致している｡これに反し､細胞内Ca^<2+>濃度の低下と結びついていると一般的に考えられている､フェニレフリン収縮標本のこれら2つの物質による弛緩は､Rp-8-Br-cGMPSによって抑制されなかった｡","subitem_description_type":"Other"}]},"item_10002_heading_23":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"原著","subitem_heading_language":"ja"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"沖縄県立看護大学"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1345-5133","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今井, 昭一"},{"creatorName":"イマイ, ショウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Imai, Shoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"仲澤, 幹雄"},{"creatorName":"ナカザワ, ミキオ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakazawa, Mikio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"豊里, 晃"},{"creatorName":"トヨサト, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Toyosato, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-15"}],"displaytype":"detail","filename":"No1p023.pdf","filesize":[{"value":"581.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"No1p023","url":"https://opcnr.repo.nii.ac.jp/record/11/files/No1p023.pdf"},"version_id":"c59dc191-a844-4a97-82ce-1db925d8c64c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ニトログリセリン","subitem_subject_scheme":"Other"},{"subitem_subject":"ニトロプルシッド","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclic GMP依存性プロテインキナーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"Rp-8-Br-cGMPS","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット大動脈","subitem_subject_scheme":"Other"},{"subitem_subject":"nitroglycerin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nitroprusside","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclic GMP-dependent protein kinase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rp-8-Br-cGMPS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rat aorta","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"cGMP依存性プロテインキナーゼのcyclic GMPによる活性化を選択的に抑制する物質であるRp-8-Br-guanosine 3',5'-cyclic monophosphorothioate(Rp-8-Br-cGMPS)の、ニトログリセリン、ニトロプルシッドによるラット大動脈平滑筋弛緩に対する作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"cGMP依存性プロテインキナーゼのcyclic GMPによる活性化を選択的に抑制する物質であるRp-8-Br-guanosine 3',5'-cyclic monophosphorothioate(Rp-8-Br-cGMPS)の、ニトログリセリン、ニトロプルシッドによるラット大動脈平滑筋弛緩に対する作用"},{"subitem_title":"Effects of Rp-8-Br-cGMPS, a selective inhibitor of activation of cyclic GMP-dependent protein kinase by cyclic GMP, on relaxation of the rat aortic smooth muscle induced by nitroglycerin and nitroprusside.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"5","path":["6"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-02-15"},"publish_date":"2021-02-15","publish_status":"0","recid":"11","relation_version_is_last":true,"title":["cGMP依存性プロテインキナーゼのcyclic GMPによる活性化を選択的に抑制する物質であるRp-8-Br-guanosine 3',5'-cyclic monophosphorothioate(Rp-8-Br-cGMPS)の、ニトログリセリン、ニトロプルシッドによるラット大動脈平滑筋弛緩に対する作用"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-06-19T06:51:25.778865+00:00"}